Scientific Program

Day 1

KEYNOTE SPEAKERS
  • POLYMERIC MATERIALS WITH NATUREBASED ADDITIVES AND REINFORCEMENTS TOWARDS COMBINED FUNCTIONALITIES

    Tampere University, Finland
    Finland
    Abstract

    All the research related to terms polymers and plastics have went through an enormous re-definition after the huge pressure established by the global recycling needs, necessary biodegradation, micro plastic waste and the fight for non-fossil source stocks for these materials. Tampere University and the Finnish plastics and composites industry are having its part in the development of new solutions to the challenge. This talk will encompass the latest achievements by our research groups and international partners, related to nano and micro- fibrillated cellulose and its use in conductive films, conductive structural materials, gas barrier membranes, natural additives of rosin and propolis in polymeric multi-filament fibres, antibacterial response of biodegradable plastics with natural components, and interfaces with synthetic and natural fibres in advanced composites. The potential to strong and tough films by the use of nano-cellulose has been for some time known. The work by properly combining optimum dispersion and surfactants with carbon nanotubes is the key to use a minimum amount of nano-additives but reach the world top conductivity. In reality, many of the film preparation methods do not allow commercial, mass production implementation and clearly up-scaled production research is necessary for industrial products. In the case of up-scaling, the control of thickness-dependent behavior, such as barrier properties, are needed to be improved and they present the current future aspect of these films and parts. Somewhat similarly, the use of nature-derive antibacterial species, such as pine rosin and bee propolis, the potential for medical applications is evident. However, the related microbial response is dependent, in a highly non-linear fashion, on a matrix of factors making the application-related optimization difficult. For example, the environment and type of encounters between material surfaces and bacterial strains is not well known due to the complex structure of natural additives. Moreover, the processing of equivalent products when applying a dosage of natural substance is typically harder. Thus, the work for effects on temperature-sensitivity, degradation, viscosity and mechanical performance is in major role in the future. When composing anisotropic, fibrous systems on a macro-scale, the advancements achieved on a nanoscale do not directly get transferred to the bulk properties. The science of interfaces and the transfer of properties towards the micro and mesoscale is the current, urgent field of much-needed research. The results gained in detailed interface-focused measurements and simulations are showing rather large gaps between the enhancement on nano and macroscale 5. To overcome the evanescence of advancements into length scale gaps, simulations and models of interfaces on various scales are necessary. References 1. Kein¨anen, P. Siljander, S. Koivula, M., et al. Heliyon2018,4(9)doi:10.1016/j.heliyon.2018.e00787 2. Siljander, S., Kein¨anen, P., Raty, A., et al. Int J Mol Sci 2018,19(6),1819doi:10.3390/ijms19061819 3. Siljander, S., Kein¨anen, P., Ivanova, A., et al Materials (Basel) 2019, 12, 430doi:10.3390/ma12030430 4. Kanerva, M., Puolakka, A., Takala, T.M., et al. Mat Today Communications 2019, In Press. doi:10.1016/j.mtcomm.2019.05.003 5. Kanerva, M., Korkiakoski, S., Lahtonen, K., et al. Compos Sci Technol 2019, 171, 6269 doi:10.1016/j.compscitech.2018.11.043 Biography

  • Effect of carbon black on properties of biodegradable composites

    Wroc?aw University of Science and Technology
    Poland
    Abstract

    An evaluation of the effects of carbon black incorporation on mechanical and electroconductive properties of biodegradable materials is presented. The biodegradable composites based on Mater-Bi® (MB) filled 1; 2; 4 wt. % of carbon black (CB) were prepared by melt mixing. Mater-Bi® is a commercial bioplastic extensively used within food packaging applications. The mechanical and electrical properties of biodegradable matrix and its composites were investigated. The electroconductive properties of prepared materials were tested to determine the percolation threshold, as well as dielectric relaxation.

  • Influence of low-frequency sonolysis on the kinetics of chemical reactions involving associates

    Russian Academy of Sciences, Russia
    Russia
    Abstract

    The effect of the association of reactants on the kinetics of reaction in the liquid phase is studied. The mathematical modelling of chemical reactions that are described by nonlinear differential equations is performed. The steady states, the conditions for the emergences of intermediates, and the nature of their concentration oscillations in the reaction system are described. The influence of low-frequency sonolysis on the kinetics of bimolecular reactions was studied with due regard for the association of dimers/trimers of starting reagents. With increasing frequency and amplitude of low-frequency sonic waves (up to some critical value), they observed the disappearance of trimers and concomitant cessation of the reaction. This observation offers an additional tool for controlling reaction rate by the external action of low-frequency vibrations.

  • Development of novel methodologies for the synthesis of ind-2-enone and piperidine-2,6-dione frameworks using Baylis-Hillman adducts

    Central University of Gujarat
    India
    Abstract

    The present day synthetic chemistry demands development of novel carbon-carbon bond forming reactions based on the concept of environmental protection. Synthetic chemists have been working in this direction for the last several years. The Baylis-Hillman reaction is one such reaction developed in recent years, on the basis of concepts of atom economy and organo-catalysis that are most important components of environmental protection. Ind-2-en-1-one framework represents an important class of carbocyclic molecules because these derivatives are found in important natural products. Some of indenone derivatives are also known to be peroxisome proliferator activated receptor ? agonists, estrogen receptor binding agents, cyclooxygenase-2 inhibitors and potent reversible inhibitors of 3CP. Due to their significant medicinal importance; development of facile strategies for obtaining such frameworks has become an attractive endeavor in synthetic organic and medicinal chemistry. Therefore development of facile strategies for the synthesis of these frameworks has become a challenging task in synthetic organic chemistry. Piperidine-2, 6-dione framework is yet another medicinally important skeleton present in several biologically active and natural products such as alonimid (sedative and hypnotic activity), thalidomide (Drug to prevent morning sickness of pregnant women), streptimidone (antibiotic), migrastatin (antitumor agent), lactimidomycin (antibiotic) and sesbanimide (antitumor). Therefore development of facile strategies for the synthesis of these frameworks has become a challenging task in synthetic organic chemistry. Hence they have developed a facile methodology using the Baylis-Hillman adducts for the synthesis of ind-2-en-1-one and piperidine-2, 6-dione framework.

3D Printing Polymers | Polymer Science and Applications | Biodegradable and Bio-Chemical Polymers | Polymer Engineering and Technology | Biopolymers and Bio-Plastics | Pharmacokinetics and Pharmacovigilance | Pharmacological science | Drug Delivery Technology
Chair
Co-Chair
Speaker
  • Sensitivity pattern of antimicrobials against uropathogens and extended spectrum beta lactamase-producing isolates in clinical specimens from the Najran Region, KSA
    Time: 14:30-14.55
    Speaker
    Saad A Alkahtani
    Najran University
    Saudi Arabia
    Biography

    Saad Alkahtani is currently Dean for College of Pharmacy at Najran University, Saudi Arabia. He is also an Associate Professor of Clinical Pharmacy, College of Pharmacy. Saad holds a PhD in Pediatric Clinical Pharmacology from the University of Nottingham, UK, 2013. He earned his Master's Degree from University of Glasgow, UK, 2009 and his undergraduate studies at King Saud University, Saudi Arabia, 1999. His research interest lies in evaluating cultural perceptions of, and access to healthcare and pharmacy services. His other research interests include pharmacoepidemiology and counterfeit medications. He has collaborated actively with researchers in several other disciplines of pharmaceutical sciences, particularly drug designing. He serves and has served in various committees at the Faculty. He is and has been a member of various national and international committees and working groups in the area of clinical pharmacy and pharmacy education. He has published many peer reviewed journal articles and conference papers and he is a reviewer for several international peer-reviewed journals.

    Abstract

    This study analyzed drug prescribing patterns for urinary tract infections (UTIs) among patients aged 12–80 years, male and female and assessed drug use in such cases. Comprised a quantitative, drug prescribing observational study and employed more than 90 confirmed cases of UTIs. The specimens investigated were collected from different hospitals in the Najran Region of the Kingdom of Saudi Arabia (KSA) and the Stokes technique was used to observe the sensitivity pattern of the isolates. The analyses showed 90.0% of total isolated organisms were Gram-negative bacteria. Among the Gram-negative and Gram-positive bacteria, Escherichia coli and Staphylococcus epidermis were the most prevalent organisms, respectively. The percentage of Gram-negative isolates was found to be the greatest for E. coli (54.83%), followed by Klebsiella (9.67%) and Sphingomonnus paucimobilis (5.37%). Among the Gram-positive isolates, the greatest occurrence was found for Staphylococcus epidermis (5.37%). The antibiotic effectiveness against different isolates was found to be greatest for Amikacin (95.2%), followed by Ceftriaxone (89.3%), Ceftazidime (88.1%) and Ciprofloxacin (84.5%). Furthermore, screening of multi-drug resistant isolates for extended-spectrum beta (?)-lactamase (ESBL) production showed that 58.33% of Gram-negative isolates produce these enzymes. Among the various bacteria, the production of EDSL enzymes was greatest for E. coli (72.54%), followed by Klebsiella and Pseudomonas aeruginosa (both 66.66%) and then Sphingomonnus paucimobilis (40.0%). The findings suggest that antibiotic resistance in UTIs shows alarming outcomes and clinical guidelines are urgently required to minimize resistance to antibiotics for the treatment of UTIs in the Najran Region, KSA.

  • Cellulose fibres hybrid chemical modification approach employed in polymer composite applications
    Time: 14:55-15:20
    Speaker
    Stefan Cichosz
    Lodz University of Technology
    Poland
    Biography

    Stefan Cichosz is a Master student at Lodz University of Technology, Poland. Till now, he is a first author of five and co-author of two publications. His works has been cited about 10 times. During the short scientific career, he has been awarded many times, e.g. a scholarship from the Minister of Science and Higher Education in Poland, the prize for the best bachelor thesis realized at the Faculty of Chemistry in the academic year 2017/2018, the prize of the Lodz University of Technology Rector for the youngest first author of a scientific article published in 2018, the title of Student of the Year 2017/2018 of the Faculty of Chemistry. He is also a manager of two scientific projects financed with The Best of The Best 3.0 and Diamond Grant 2019 programs (Ministry of Science and Higher Education in Poland). At the beginning of the following academic year, he is going to start his PhD studies.

    Abstract

    Following research study highlights the importance of an indispensable process in cellulose fibres (Arbocel UFC100 – Ultra Fine Cellulose) modification, which may easily change the biopolymer properties-drying. Study provides a broad range of information considering the drying process consequences on the chemical treatment of the cellulose and properties of cellulose-filled polymer composites based on an ethylene-norbornene copolymer (TOPAS Elastomer E-140). This research underlines the importance of UFC100 moisture content reduction, considering polymer composites applications, with the employment of techniques different than thermal treating. Therefore, a new hybrid chemical modification approach is introduced (Fig). It consists of two steps: Solvent exchange (With ethanol either hexane) and chemical treatment (maleic anhydride - MA). Hybrid chemical modification of cellulose fibres: Path 0 – regular surface modification with MA, Path 1 – solvent exchanges before the surface modification with MA, Path 2 – solvent exchange after the surface modification with MA. What should be emphasized, in case of all carried out UFC100 treatments a decrease in moisture content was evidenced. Nevertheless, it may be claimed that ethanol employment highly contributes to the lowering of water absorption ability of cellulose (up to 1.65%). Moreover, regarding composite specimen mechanical properties, the highest performance improvement was noticed in case of TOPAS + UFC100/ND/MA/1/E sample. Here, not dried cellulose has been modified with MA after a solvent exchange with ethanol. What is more, in case of that sample, also an improvement in storage modulus has been detected. Both Payne effect and filler efficiency factor indicate a possibility of a filler reinforcing nature. In performed research new filler hybrid modification approach, being undoubtedly a scientific novelty is introduced. Moreover, valuable data considering composite properties filled with cellulose fibres of various moisture content have been provided (Thermal, mechanical and structure).

  • Zinc doped magnetic prepared nanoparticles its assessment
    Speaker
    Mamdouh I Nassar
    Cairo University, Egypt
    Egypt
    Biography

    * Ph.D degree,1995 for pests management, University of Maryland, (USA) and the Cairo University channel system. * Msc. degree in 1989, Biology ,Entomology Department, Faculty of Science, Cairo University. * Bsc. degree, Biology Department, Faculty of Science, Cairo University in 1983. * Professor, Faculty of Science, Cairo University 3/2006. * Assistant Professor, Faculty of Science, Cairo University, 2002. * Associate Professor, Biology Department - Faculty of Science, King Khalid University Saudi Arabia in 2003. * Lecturer at the Faculty of Science, Cairo University in 1995. * Visiting Professor at the University of Maryland 1992-1994m animal science department. * Assistant Lecturer at the Faculty of Science, Cairo University in 1992. * Lecturer in the Faculty of Science, Cairo University in 1984.

    Abstract

    Nanoparticle metal oxides represent a new class of important materials that developed use in researches of medical, biotechnology and microbial prevention. This study clearly demonstrated that Zinc nanoparticles have a wide range of antimicrobial effects. The antibacterial activity of Zinc may be dependent on its size. The data suggest that ZnO2 and ZnN2 nanoparticles were inhibited growth and damage of bacterial cells. The aim of this study was to evaluate antimicrobial activity properties of Zinc doped magnetic prepared in O2 and N2 against Escherichia coli K88 bacteria. Results of this study revealed that ZnO nanoparticles caused inhibition zone diameter before heating by 25, 24, 23, and 22 mm. at nanoparticles concentrations of Zn 0.25% doped in O2, Zn 0.2% in O2, Zn 0.15% in O2 and Zn 0.3% doped in O2 respectively. While ZnN2 nanoparticles produced diameter inhibition of E. coli by 20, 17, 16 and 15mm at nanoparticle concentrations of Zn 0.25% in N2, Zn 0.15% in N2, Zn in N2 and Zn 0.1% & 0.3% respectively. Data showed that Zn doped in O2 and N2 nanoparticles were decreased and prevented growth of E. coli colonies. The most effective prevention was 37% by the effect of Zn 0.2% doped in O2 zone of inhibition diameter increases as the density of the nanoparticles increased. After heating the highest inhibition of zone diameter was 27mm at nanoparticle concentration of Zn 0.25% doped in O2. Also the nanoparticles of Zn 0.2% doped in O2 most produced prevention of E. coli growth colony by 37%. Meanwhile these results concluded there is no clear significant different P ? 0.5 by the effect of ZnO2 and ZnN2 before or after heating. It can be concluded that the results from the premises for future studies on high quality and nanoparticles materials that could be used eventually in various biomedical and microbial prevention applications.

  • Operation room IV medication management
    Time: 15.45-16.10
    Speaker
    Kabeer Ahmad
    Los Angles Hospital Management and IVPN
    United Arab Emirates
    Biography

    Kabeer Ahmad completed his Doctor of Pharmacy from Sarhad University of Science and Information Technology, Pakistan at 2009, Good Clinical Practices from Brook Wood International academy London 2016. He is the Member of IVPN Abu Dhabi. He is Practicing Pharmacist with Los Angles Hospital Management.

    Abstract

    Operation room IV Medication Management will discuss the automated device system and activation in the operating room. Discuss the customized IV medication management system. Discuss the experience at CCAD with OR IV Medication management. Completely automated system using automated dispensing machines and computerized physician order entry. ADM and stock of medication in operating room are completely managed and controlled by pharmacist. Operation Room is unique environment, frequent use of high alert medications; risk of error in OR higher than other specialties due to its immediate and urgent nature. Patient-unstable majority, error/near miss of one in every 274 anesthetics medicines administrated. Evidenced based strategies to enhance medication safety all based around IV medication management –STPC (Standardization Technology Pharmacy Culture). Standardization of Pharmacy why?: Concentration different pharmacy and anesthesia prepared on patient returning ICU; Decreased waste; Decreased inefficiencies and delays in process; Reduce potential for errors; Ultimately reduce patient harm; Concentration of majority of IV medication prepared and commercially available; Dosing united of medication ; Dosing limits and rates and methods of infusing syringe or bag. Standardization of pharmacy how?: Pharmacy prepare standard drips and syringes eliminating need of IV medications to be prepared by anesthesia within the OR, standardization of one concentration for all IV medication as well as standardization of the double concentration of the double concentration of vasoactive drugs. All products stocked in ADM are the same concentration and volume and same locations. Challenges: Physicians/Anesthesia buy in; wastage high still financial concern; ADM accurate usage- multiple effects and training of staff. Conclusion: Pharmacy/Anesthesia collaboration improved the process and outcomes. Pharmacist role in OR is beyond technical platform rather a steward for medication management. Collaboration allowed for 98% of IV medicines availability within the OR proper use of ADMs is critical to optimize medication use in the OR justifies cost.

  • Biopolymers as sustainable raw material for textile industry: An opportunity or a challenge
    Time: 16:30-16:55
    Speaker
    Pavan Kumar Manvi
    RWTH Aachen University
    Germany
    Biography

    Dr.-Ing. Pavan Kumar Manvi is head of the research group “Biopolymer” at Institut für textiltechnik of RWTH Aachen University, where he has been since 2011. From 2011 till 2016 he served as researcher in the field of melt spinning of biopolymers. In 2016, he founded biopolymer research group and serving as head of the research group till date. During 2016-2018 he was a visiting scientist at Maastricht University. He received his Ph.D. on the topic of melt spinning of carbon dioxide based thermoplastic polyurethane. His research interests lies in the field of sustainable materials in the textile applications. Much of his work has been on improving the understanding and designing melt spinning process for biopolymers and improving performance during filament processing. For his achievements and excellent work, he got best poster prize in Applied Biopolymer Conference 2017 in Maastricht and first poster prize in International Conference on Biobased Textiles and Plastics 2018 in Gent. Working as a researcher after PhD, he is concentrating now not only sustainable fiber and process development but also on tailoring functionality of biopolymer fibers using additives and filament surface area. Major concentration is given on development of tailor-made biodegradability in the filaments.

    Abstract

    Use of polymer in household as well as in industrial applications is increasing day by day due to their unique properties. Majority of polymers is derived from petroleum oil, which also poses enormous environmental problems in terms of global warming and pollution. Depleting reserves of petroleum oil and strong fluctuations in the crude oil prices make the search of alternatives necessary. So called biopolymers are polymeric materials, which are produced from renewable materials or biodegradable or both. The use of biopolymers in polymer and textile industry not only reduces carbon footprint but also provides independency from petroleum oil. A transition from petroleum based resources to bio-based resources has seen as an opportunity. Despite increasing interest in the sustainable raw materials, a shift from petroleum based resources to bio-based resources is seen as a long awaiting milestone in the polymer industry. The challenges are associated not only with higher price than conventional polymers but also with the limited process ability and the inadequate properties. The development of biopolymers has been a long history in different generations of development. The biopolymers of first generation i.e. starch, cellulose etc. were directly extracted from the natural resources and implemented in different polymer processing routes. However, natural polymer in their raw form had enormous difficulties in the processing due to undesired polymer structure, morphology, lack of homogeneity and presence of impurities. An efficient solution was seen as depolymerizing bio-based raw materials and using the clean monomers for polymer synthesis. This led to the second generation of biopolymer, so called synthesized biopolymers having desired molecular structure and tailored polypeptides i.e. polylactic acid. The modification in the structure of synthesized biopolymers is still a major topic of research and gaining a lot of attention. Despite, enormous potential of synthetic biopolymers, they are showing competition with food and feed. It seems challenging to fulfil the world polymer demand by synthesized bio-based polymers without endangering food and feed capabilities. Development of biopolymers from industrial, agricultural and household waste is seen as effective solution to fulfil world's demand without endangering food demand. Development of polyhydroxyalkanoates from waste and thermoplastic polyurethane (partially) from carbon dioxide is seen as potential solution. Research group "Biopolymer" at Institut fur Textiltechnik of RWTH Aachen University is devoted to find out the potential of biopolymers in textile application, developing textile process chain for interdisciplinary application and aiming at turning challenge with biopolymers into an opportunity for textile industry.

  • Title: Pharmacokinetics and Toxicity Challenges to Delivery of Cancer Nanomedicines
    Speaker
    Rakesh Dixit
    Bionavigen, USA
    USA
    Biography

    • President & CEO, BIONAVIGEN, LLC, a biopharmaceutical virtual drug development company specializing in advising and consulting for all aspects of drug development, including discovery, preclinical development, CMC, translational sciences, clinical development and regulatory filing. • Selected by pharmaceutical peers as the 100 Most Inspiring People in Pharmaceutical Industry by PharmaVOICE in 2015 • Accomplished executive, inventor, and scientist with over 30 years of success with top biotechnology and pharmaceutical companies, including Merck, Johnson & Johnson, Medimmune, AstraZeneca.

    Abstract

    Nanomedicines are increasingly being used to diagnose, prevent, and treat human diseases. Nanotechnological advances are enabling targeted delivery of difficult to deliver innovative therapies, including gene editing and disease correcting gene delivery, highly lipophilic cytotoxic cancer drugs, mod RNA, etc. Although nanomedicines offer great opportunities for targeted delivery, they have increasingly faced safety, disposition, CMC and manufacturing challenges that have limited their utility. With special emphasis on safety and pharmacokinetics, the presentation will discuss the safety, pharmacokinetics, CMC, and other challenges in the development of nanomedicines with emphasis cancer therapeutic nanomedicines.

Day 2

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